Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates

Article Abstract:

A highly purified RNA polymerase II transcription system containing chromatin templates assembled with purified histones and assembly factors, the histone acetyltransferase p300, and components of the general transcription machinery for activation transcription (initiation and elongation) on DNA templates is reconstituted. The study shows that this system mediates activator-dependent initiation, but not productive elongation, on chromatin templates.

RNA polymerases

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A topological interaction between cohesion rings and a circular minichromosome

Article Abstract:

A method of detecting cohesion's association with small ring chromosomes after their purification from extracts prepared from M phase cells is developed to investigate whether cohesin binds chromatin physically or traps it topographically. The stable association between cohesion and chromatin is topological rather than physical, which is consistent with the notion that DNA is trapped inside cohesion rings.

Chromosomes

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Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis

Article Abstract:

The H3.1 and H3.3 complexes contain distinct histone chaperones, CAF-1 and HIRA, that are necessary to mediate DNA-synthesis-dependent and -independent nucleosome assembly. Finding of the H3.1 and H3.3 complexes gives new insights into possible mechanisms for maintenance of epigenetic information after chromatin duplication.

Genetic research, Nucleosomes, Molecular chaperones

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