The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor

Article Abstract:

Results demonstrate that the bone morphogenetic protein-4 activity and signaling capability is influenced by its cleavage sites mediated by furin. Data show that cleavage at a consensus furin site enables subsequent cleavage at a nonconsensus site. The protein cleaved at two sites are more active and signal over a greater range.

Analysis, Physiological aspects, Proteins, Cellular signal transduction, Protein structure, Scission (Chemistry), Bone morphogenetic proteins

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Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation

Article Abstract:

Results demonstrate that synergistic regulation of vertebrate muscle development involves Drosophila gene dachshund2, vertebrate homologs Eya2 and Six1 and physical interaction between the respective gene encoded proteins. This study illustrates a new regulatory pathway for myogenic specification in the embryonic precursors of the skeletal muscle development.

Statistical Data Included, Research, Development and progression, Striated muscle, Drosophila, Myogenesis, Somite, Somites (Embryology)

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