TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism

Article Abstract:

Research has been conducted on tissue inhibitors of metalloproteinases (TIMPs) which suppress the activity of matrix metalloproteinases. The authors report the establishment of the matrix metalloproteinase-independent mechanism for TIMP-2 inhibition of endothelial cell proliferation in vitro.

Neovascularization, Endothelium, Cell proliferation, Metalloproteins

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Ubiquitinating a phosphorylated Cdk inhibitor on the blades of the Cdc4 beta-propeller

Article Abstract:

The author discusses substrate binding by ubiquitin ligase which is regulated by phosphorylation. The topics of interest include the crystal structure of Cdc4 subunit bound to high-affinity substrate phosphopeptide.

Phosphorylation, Crystal structure

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The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by COP9 signalosome in response to DNA damage

Article Abstract:

Research has been conducted on nucleoside excision repair. The authors demonstrate that UV response of the DDB2 and CSA complexes affect nucleoside excision repair mechanism.

Japan, Biological Product (except Diagnostic) Manufacturing, Nucleic Acid Derivatives, DNA damage, Genetic regulation, Nucleosides

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