TNF-alpha, IL-1-alpha, IL-6 and ICAM-1 expression in human keratinocytes stimulated in vitro with Escherichia coli heat-shock proteins

Article Abstract:

Blocking experiments using monoclonal antibodies were done to study the role of the Escherichia coli heat shock proteins (HSPs) in cytokine expression in human keratinocytes. The cytokines examined included tumor necrosis factor-alpha, interleukin-1-alpha, interleukin-6 and intercellular adhesion molecule-1. The results confirmed that the bacterial HSPs can induce the expression of cytokines, indicating that the proteins modulate cell interactions associated with immunological and inflammatory responses in the skin.

Usage, Heat shock proteins, Keratinocytes, Monoclonal antibodies, Cytokines, Tumor necrosis factor, Immune response, Immunoassay

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Lymphatic vasculature: a molecular perspective

Article Abstract:

Various studies provide insights into developmental processes and molecular mechanisms controlling the formation and remodelling of the lymphatic vessels. The current understanding of the mechanisms of lymphatic development and contribution of lymphatic vessels to pathological conditions are reviewed and the essential and active role of lymphatic vessels in various pathological conditions is demonstrated.

United States, Blood vessels, Molecules, Lymphatic vessels, Molecular modeling

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The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling

Article Abstract:

Interleukin-15 (IL-15) is a pleiotropic cytokine of the 4 alpha-helix bundle family, which blends to a receptor complex that displays common elements with the IL-2 receptor and a unique high-affinity alpha chain. The review focuses on juxtacrine and reverse signaling levels in the IL-15/ Il-15R system.

Germany, Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Interleukin, Health aspects, Care and treatment, Immunologic diseases

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