Targeting genes for self-excision in the germ line

Article Abstract:

A process that directs self-induced deletion of DNA sequences as they go through the mouse male germ line has been described. The testes-specific promoter from the angiotensin-converting enzyme gene was used to drive expression of the Cre-recombinase gene. Somatic cells from the embryo-derived stem (ES) cells retained the cassette, but self-excision took place in all ES-cell-derived sperm.

Genetic aspects, DNA, Testis, Mice, Mice (Rodents), Genetic regulation, Spermatozoa, Sperm, Antibody diversity

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Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: Cooperativity of Ink4a/ARF and Trp53 loss of function

Article Abstract:

The first mouse model of alveolar rhabdomyosarcoma is reported using a conditional Pax3:Fkhr knock-in allele whose activation in late embryogensis and postnatally is targeted to terminally differentiating Myf6-expressing skeletal muscle. This report provides an important starting point for understanding the initiation and progression of the tumor and its potential cells of origin.

Science & research, Observations, Muscles, Genetic research, Rhabdomyosarcoma, Skeletal muscle

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