Terminating the transcript: Breaking up is hard to do

Article Abstract:

Transcription termination occurs when a transcribing RNA polymerase releases the DNA template and the nascent RNA. Termination is required for preventing the inappropriate transcription of downstream genes and for recycling of the polymerase, and two models are discussed to address the mechanistic basis for the connection between termination and cleavage/polyadenylation.

United States

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BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II

Article Abstract:

Evidence regarding the transient inhibition of the pre-mRNA 3' processing machinery, which involves proteasomal degradation of a component necessary for processing, RNA polymerase II (RNAP II) is provided. This study shows that RNAP IIO, the elongating form of the enzyme, is a specific in vitro target of the BRCA1/BARD1 ubiquitin ligase activity.

Genetic research, Ubiquitin

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The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination

Article Abstract:

The formation of 3' end and termination of transcription is promoted by association of XRN2 with p54nrb/NonO (p54)-protein-associated splicing factor (PSF).

Protein research

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