Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure

Article Abstract:

Evaluation of the robustness of the likelihood-ratio test is discussed as it relates to a variance-component quantitative-trait loci-mapping procedure. For sib-pair studies the test has been evaluated using simulation and results showed some kinds of nonnormality and type I error-rate inflation apparently directly related to the residual sibling correlation, although multivariate normality is usually assumed.

Italy, Statistical Data Included, Usage, Mathematical models, Variation (Biology), Probabilities, Probability theory, Medical statistics, Linkage (Genetics)

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Allowing for missing parents in genetic studies of case-parent triads

Article Abstract:

Researchers can still obtain viable data even if parent or proband genetic data is unavailable. By using the likelihood-ratio test, researchers are able to complete parent-child genetic triads through the test's expectation-maximization algorithm. The transmission/disequilibrium test, however, would require researchers to abandon the incomplete triad, and risk the elimination of important discoveries.

Models, Genetic disorders, Genetic research

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