Social life and the single nucleotide: foraging behavior in C. elegans

Article Abstract:

Natural isolates of Caenorhabditis elegans display either dispersing or clumping feeding behavior. The npr-1 gene, which encodes a predicted G protein-coupled receptor similar to neuropeptide Y receptors, causes the dispersing C. elegans strain to take on a clumping behavior. Only two alleles of npr-1 that differ by a single nucleotide are found in C. elegans. One is found exclusively on clumping strains, while the other exclusively on dispersing strains.

Genetic aspects, Social behavior in animals, Animal social behavior

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Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model

Article Abstract:

The gram-negative bacterium Pseudomonas aeruginosa is an opportunistic pathogen whose versatile virulence mechanisms make it quite deadly because they enable it to survive in a number of natural and hospital environments. A study employing the systematic mutagenesis of P. aeruginosa strain PA14 which kills Caenorhabditis elegans to identify mutants which fail to kill C. elegans and a study C. elegans mutants may be useful in cellular immunity research.

Gram-negative bacteria, Pseudomonas aeruginosa, Virulence (Microbiology), Gram-negative bacterial infections, Cellular immunity, Natural immunity

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