The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

Article Abstract:

Results shpw that mutations in the mammalian Mst1 and Mst2 related hippo protein kinase cause enhanced tissue growth and reduced apoptosis as revealed by elevated levels of cell cycle regulator cyclin E and apoptosis inhibitor DIAP1. Data indicate that interaction between hippo encoded protein and serine/threonine kinase and salvador gene encoded protein regulate DIAP1 possibly by hippo protein-mediaed phosphorylation and degradation.

United States, Physiological aspects, Gene mutations, Gene mutation, Cellular control mechanisms, Cell regulation, Protein kinases, Cell proliferation, Apoptosis

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A pericellular collagenase directs the 3-dimensional development of white adipose tissue

Article Abstract:

The membrane-anchored metalloproteinase, Mt1-MMP, coordinates adipocyte differentiation in vivo. MT1-MMP acts as a 3-D-specific adipogenic factor that directs the dynamic adipocyte-ECM interactions critical to white adipose tissue development.

Science & research, Research, Adipose tissues, Adipose tissue, Genetic research, Fat cells, Adipocytes, Collagenases

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