Paul Sigler (1934-2000)

Article Abstract:

The life of Paul Sigler, M.D., (1934-2000) is discussed in this obituary article. Sigler and his wife were dedicated Democrats and anti-racists and worked for equality. He found himself more interested in research in protein crystallography than in medical practice and joined the National Institutes of Health. Sigler and colleagues studied how chaperonins, protein-folding machines in the cells, work and figured out structures of GroEL and GroEL-GroES-(ADP)(sub.7). Shortly before his death the GroEL-peptide complex structure was discovered with his help.

Obituary, Chemists, Crystallography, Protein folding, Crystallographers, Sigler, Paul

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The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior

Article Abstract:

A novel Drosophila circadian clock-regulate output gene, takeout (to), has been characterized. The gene is a novel molecular link between circadian rhythms and feeding behavior. The amino acid sequence of the gene is similar to two ligand-binding proteins, including juvenile hormone binding protein.

Physiological aspects, Carrier proteins, Transport proteins, Hormones, Circadian rhythms, Food habits

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Modulation of a transcription factor counteracts heterochromatic gene silencing in Drosophila

Article Abstract:

Modulation of a transcription factor has been found to counteract Drosophila heterochromatic gene silencing. A conditional system that makes probing of heterochromatin possible at a reporter GFP gene by altering GAL4 transcription factor levels in eye development was used in a study. The frequency of gene silencing was, surprisingly, highly sensitive to GAL4 levels. It appears that binding site occupancy affects the silenced state. Variegation seems to be found when heterochromatin inhibits transient exposure of factor binding sites.

Developmental biology, Genetic transcription, Transcription (Genetics), Eye

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