The Homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient

Article Abstract:

A study showed that in mice lacking the homeodomain transcription factor Irx5, the cardiac repolarization gradient was abolished due to increased Knu4.2 potassium-channel expression in endocardinal myocardium, resulting in a selective increase of the major cardiac repolarization current, I(sub to,f) and increased susceptibility to arrhythmias. It was found that Irx5 repressor gradient negatively regulated potassium-channel-gene expression in the heart.

Genetic research

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Making or breaking the heart: From lineage determination to morphogenesis

Article Abstract:

The conceptual advances in cardiac morphogenesis in the context of congenital heart disease and adult onset heart disease are reviewed. A deeper understanding of the interactions between various signaling and transcriptional networks and their ultimate downstream targets would be necessary to identify potential approaches in at-risk parents.

Genetic aspects, Congenital heart disease, Congenital heart defects, Morphogenesis

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Homeobox galore: When reproduction goes RHOX and Roll

Article Abstract:

A new homeobox gene cluster composed of genes selectively expressed in reproductive tissues is described. The cluster is found to be on the X chromosome and the genes display a colinear pattern of expression.

Chromosomes

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