The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila

Article Abstract:

The Drosophila Extradenticle (Exd) protein is a cofactor to homeotic proteins and has regulated nuclear localization. The Drosophila homothorax (hth) gene has been cloned. It is a homolog of the mouse Meis1 proto-oncogene that has a homeobox related to the exd homeobox. The Homothorax homeoprotein suppresses eye development in Drosophila. Hth acts upstream from exd and is required and adequate for Exd protein nuclear localization. It is likely hth works with exd to give parameters to the eye field and to prevent eye development that is not appropriate.

Proteins, Eye, Molecular biology

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Control of the nuclear localization of Extradenticle by competing nuclear import and export signals

Article Abstract:

Control of the nuclear localization of Extradenticle (Exd), the Drosophila PBC protein, has been investigated. Competing nuclear import and export signals are involved. Exd is regulated at the level of its subcellular distribution. Three elements in Exd have been identified. It seems there is a balance between activities of an nuclear export signal (NES) and a nuclear localization sequence (NLS) and that Homothorax (Hth) changes the balance in favor of the NLS.

United States, Developmental biology, Genetic disorders

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pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

Article Abstract:

The Drosophila gene pavarotti encodes a protein, PAV-KLP, that resembles kinesin. Mutations in the gene result in defects that appear at cytokinesis. The protein, a homolog of mammalian MKLP-1, is apparently needed to organize the central spindle in telophase, enabling the contractile ring to be assembled. PAV-KLP may also play a role in mobilization of proteins that regulate mitosis.

Spindle (Cell division), Spindle (Cytoplasm), Cytokinesis

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