Pausing for thought on the boundaries of imprinting

Article Abstract:

Boundaries of imprinting are discussed in this review article, which deals with whether a switch that occurs in fission yeast and is determined by replication and by a replication pause site and other epigenetic phenomena in which chromosomal domains are heritably repressed might have things in common with the mechanisms used to set up or propagate imprinting in mammals. Topics include methylation-sensitive boundary element and mutually exclusive Igf2 and H19 expression, propagating epigenetic states in absence of initial stimulus, and replicating the chromatin landscape. Questions still exist relative to the silent imprinted alleles on mammal chromosomes.

United Kingdom, Mammals, Chromosomes, Gametogenesis

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swi 1 and swi3 perform imprinting, pausing, and termination of DNA replication in S. pombe

Article Abstract:

The mating type of Schizosaccaromyces pombe has been found by the mating-type locus (mat1) at chromosome II, and according to the model developed, leading-strand replication brings on a break when the replication fork encounters the imprint lagging-strand replication brings at mat1. Likely swi 1 and swi3 perform imprinting and pausing of DNA replication. Likely they promote imprinting in novel ways, among them terminating replication at RTS1.

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The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p

Article Abstract:

The Isw2 chromatin remodeling complex of Saccharomyces cerevisiae has been found to repress early meiotic genes upon recruitment by Ume6p. Nuclease digestion analyses were used to show the Isw2 complex establishes a nuclease-inaccessible chromatin structure near the Ume6p binding site in vivo. A model for the mechanism of transcriptional repression by two chromatin remodeling complexes is proposed.

Genetic regulation, Genetic transcription, Transcription (Genetics)

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