Follow the leader: NK cell receptors for classical and nonclassical MHC class I

Article Abstract:

Natural killer (NK) cells engage in the innate immune response against a number of viruses, intracellular bacteria, transformed cells and parasites. They kill cells that lack major histocompatibility complex (MHC) class I on the cell surface and have been observed to express receptors for MHC class I that inhibit NK cell-mediated cytotoxicity and cytokine secretion. Moreover, classes of membrane receptors that associate with NK cells bind MHC class I ligands and prevent the destruction of class I-bearing cells.

Physiological aspects, Major histocompatibility complex, Cell physiology

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Natural killer cell receptors: the offs and ons of NK cell recognition

Article Abstract:

Target cell lysis by natural killer (NK) cells is controlled by a balance between distinct activating and inhibitory receptors. The class I inhibition of NK cells is attained by class I-specific NK cell receptors. The structure and expression of p58 and Ly49 inhibitory receptors and the isoforms of p58-related receptors are discussed.

Research, Cellular recognition

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