The SRC-3/AIB1 Coactivator is degraded in a Ubiquitin- and ATP- Independent manner by the REG(gamma) proteasome

Article Abstract:

Cellular levels of REG(gamma) expression affect estrogen-receptor target-gene expression and cell growth as a result of its ability to promote degradation of the SRC-3 protein. In vitro proteasome proteolysis assays using purified REG(gamma), SRC-3, and the 20S proteasome reinforce these conclusions and demonstrate that REG(gamma) promotes the degradation of SRC-3 in a ubiquitin- and ATP-independent manner.

China, Analysis, Ubiquitin, Cell physiology, Ubiquitin-proteasome system

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

Article Abstract:

The mechanism by which the loss of HIC1 function promotes tumorigenesis is via activating the stress-controlling protein SIRT1 and thereby attenuating p53 function. HIC1 forms a transcriptional repression complex with SIRT1deacetylase, and this complex directly binds SIRT1 promoter and represses its transcription, allowing cells to survive DNA damage.

DNA damage, Tumor suppressor genes, Tumour suppressor genes

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