The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment

Article Abstract:

Segmentation polarity genes in Drosophila melanogaster are activated by pair rule gene activity. Suppressor of fused (Su(fu)) is a dominant suppressor of the fused gene that has been designated as a tool of analysis for regulatory pathways in gene activity. The Su(fu) protein is characterized by a PEST sequence and exhibited no substantial homologies with known proteins. Ideal segment formation is conditioned by appropriate genetic doses of fu and Su(fu).

Physiological aspects, Suppression, Genetic, Suppressor mutation (Molecular genetics), Morphology (Animals), Animal morphology

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Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs

Article Abstract:

The role of Suppressor of fused protein, which is antagonized by the Fused protein, as a negative regulator of Hedgehog target gene expression in embryonic development of Drosophila is examined.

Analysis, Gene expression, Embryology

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Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila

Article Abstract:

The negative impact of atrophin in controlling epidermal growth factor receptor (EGFR) signaling in Drosophila is studied.

United Kingdom, Epidermal growth factor receptors

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