Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway

Article Abstract:

The tumor necrosis factor-[alpha] (TNF[alpha])-mediated inhibition of myogenic differentiation is found to be dependent on p53 through a PW1-mediated pathway. The p53 plays a novel role in mediating muscle stem cell behavior and muscle atrophy, and has pointed towards new targets for the therapeutic treatment of muscle wasting (cachexia).

Cell death, Tumor necrosis factor, Muscle diseases, Muscular diseases, Cachexia, Tumour necrosis factor

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'Drosophila' PIWI associates with chromatin and interacts directly with HP1a

Article Abstract:

The PIWI protein interacts with heterochromatin protein 1a (HP1a) in 'Drosophila' and is a chromatin-associated protein. A direct interaction between PIWI and HP1a determines the epigenetic state of the genome.

Genetic aspects, Chromatin, Protein binding, Epigenetic inheritance

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