The Caenorhabditis elegans fate-determining gene mab-9 encodes a T-box protein required to pattern the posterior hindgut

Article Abstract:

The Caenorhabditis elegans fate-determining gene mab-9 has been cloned. It has been shown that it encodes a T-box protein that is necessary for patterning the posterior hindgut of C. elegans. MAB-9 localizes to the nucleus of B and F, two posterior blast cells.

Developmental genetics

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Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif

Article Abstract:

Regulation of the activin-inducible distal element of the Xenopus goosecoid promoter has been studied. Winged-helix and homeodomain transcription factors bring activated Smads to certain promoter elements through a common Smad interaction motif. A model is proposed for mesoendoderm formation in Xenopus. In it the homeodomain transcription factor/Smad complexes have a role in transcription of target genes, responing to endogenous activin-like signals.

Physiological aspects, Genetic transcription, Transcription (Genetics), Xenopus, Mesoderm

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The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode Caenorhabditis elegans

Article Abstract:

The coronin-like protein POD-1 in the nematode Caenorhabditis elegans is is discussed. It is required for anterior-posterior axis formation and cellular architecture. An effort is being made to understand the role of filamentous actin (F-actin) in setting up polarity. F-actin-binding proteins were isolated from C. elegans oocytes. A deletion within the pd-1 gene has been generated. Models that explain how the role of POD-1 in basic cellular processes links to polarity generation on the embryonic a-p axis are proposed.

United States, Statistical Data Included, Developmental biology, Embryology, Experimental, Embryological research, Actin, Cytoskeleton, Polarity (Biology)

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