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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

Article Abstract:

Research shows that misfolded protein-induced stress is managed by the microtubule-associated deacetylase, HDAC6, which is a component of the aggresome. The HDAC6 binds both polyubiquinitated misfolded proteins and dynein motors and recruit misfolded proteins to dynein motors for transport to aggresomes.

Author: Yao, Tso-Pang, Vance, Jeffery M., Kawaguchi, Yoshiharu, Kovacs, Jeffrey J., McLaurin, Adam, Ito, Akihiro
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
Analysis, Stress (Physiology), Gene expression, Dynein

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Interleukin 20: discovery, receptor identification, and role in epidermal function

Article Abstract:

Bioinformatics analysis reveals the discovery of a novel interleukin 10 homolog, interleukin 20. The new cytokine causes neonatal lethality and aberrant epidermal differentiation. Recombinant interleukin 20 mediates signal transduction in keratocyte cells.

Author: Madden, Karen, Parrish-Novak, Julia, Foster, Donald W., Haugen, Harald, Blumberg, Hal, Conklin, Darrel, Xu, WenFeng, Grossmann, Angelika, Brender, Ty, Carollo, Susan, Eagan, Maribeth, Haldeman, Betty A., Hammond, Angie, Jelinek, Laura, Kelly James D., Mauer, Mark F., Prunkard, Donna, Sexson, Shanon, Sprecher, Cindy, Waggie, Kim, west, Jim, Whitmore, Theodore E., Yao, Lena, Kuechle, Melanie K., Dale, Beverly A., Chandrasekher, Yasmin A.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
Interleukins, Psoriasis, Epidermis, Computational biology, Interleukin structure-activity relationships

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ICEBERG: a novel inhibitor of interleukin-2beta generation

Article Abstract:

ICEBERG, a member of the death-domain-fold superfamily, has been found to be a novel inhibitor of interleukin-2beta generation. It may be part of a negative feedback loop, being induced by proinflammatory stimulae.

Author: Humke, E.W., Shriver, S.K., Starovasnik, M.A., Fairbrother, W.J., Dixit, V.M.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
Statistical Data Included, Genetic aspects, Cell death, Inflammation, Cytochemistry, Interleukin-2

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Subjects list: United States, Physiological aspects, Protein folding, Research, Cytokines
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