The effects of selection on linkage analysis for quantitative traits

Article Abstract:

A study was conducted to evaluate effects of within-sample selection on linkage analyses between genetic markers and quantitative traits. Results show that truncation for the trait of interest decreases variation between marker genotype means. The process reduces the power to identify linked quantitative trait loci (QTL). The reduction size is conditioned by proportion selected, magnitude of QTL effect, recombination rate between marker locus and QTL and QTL allele frequency.

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The evolution of multilocus systems under weak selection

Article Abstract:

The two-locus system is analyzed and transformed to a more general multilocus model using quantitative genetics. The terms and symbols used in the analysis are listed in tabular form. Using preliminary solutions, it is shown that linkage disequilibria becomes small both for two-loci and mutlilocus systems. Derivations include approximations on the linkage-equilibrium surface and on variations of the linkage disequilibria. Linkage equilibria is related to epistasis.

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Linkage and the limits to natural selection

Article Abstract:

Fitness variations at loci selections conditioned the fixation probability for a favorable mutation. Such an allele probability can be measured and integrated with the impact of substitution, polymorphism variations and mutations for a large population. Effects can be quantified by effective population size decreases due to heritable fitness changes under loose linkage conditions. Different results are obtained for tight linkage cases.

Variation (Biology)

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