The genetics of cellular senescence

Article Abstract:

Genetic factors appear to play a significant role in replicative senescence of cells. Thus, cellular senescence does not seem to be a result of passively accumulating errors, but rather an active process governed by genetic programs. Somatic cell-hybrid studies indicate that cellular senescence is genetically dominant. Progressive impairment of mechanisms of tumor suppression may be involved. A process of incomplete replication that causes shortening of telomeres may also limit the number of divisions cells undergo.

Aging

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Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor

Article Abstract:

The transformation potential of Simian Virus 40 depends on the activities of large T-antigen (LTag), which interacts with several cellular tumor suppressors including the important guardian of the genome, p53. Inhibition of p53 function by LTag is necessary for both efficient vital replication and cellular transformation.

Analysis, Tumor suppressor genes

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Overcoming cellular senescence in human cancer pathogenesis

Article Abstract:

Overcoming cellular senescence and a minimum of two genetic changes in several combinations seem essential for the human cancer pathogenesis. The genetic changes should include either p16 or pRb loss and involve an alteration such as +20q11-q12 or -8p21-pter. The research details are provided.

Cancer, Cancer genetics

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