The genetics of hereditary colon cancer

Article Abstract:

A study was undertaken to determine whether colon cancer was a hereditary phenomenon. Results revealed that the familial adenomatous polyposis (FAP), a rare autosomal disorder might be responsible for colon cancer in individuals.

Analysis, Causes of, Risk factors, Genotype, Genotypes, Polyposis, Familial, Familial polyposis, Colon cancer, Nucleotide sequencing

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The molecular pathogenesis of pancreatic cancer: Clarifying a complex circuitry

Article Abstract:

The molecular pathogenesis of pancreatic ductal adenocarcinoma (PDAC or PDA) and precursor lesions is presented. The mouse models are used as a platform for molecular diagnostics, prognosis and targeted therapeutics.

Cancer, Cancer genetics, Pancreatic cancer, Report

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The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation

Article Abstract:

Esophageal epithelial cells are used as a platform to recapitulate esophageal squamous cell cancer thereby providing insights into the molecular pathogenesis of squamous cell cancers.

Prognosis, Gene expression, Cancer invasiveness, Esophageal cancer, Fibroblasts

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