The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV

Article Abstract:

The production of two mutacins by one strain is studied, using the UA140 strain of Streptococcus mutans, a major contributor to dental caries. The mutacins or antimicrobial substances produced are the bacteriocin mutacin IV, a ribosomally synethsized peptide antibiotic, and mutacin I, a lantibiotic; their presence and effects in the oral cavity are also discussed.

United States, Statistical Data Included, Analysis, Usage, Physiological aspects, Dental caries, Bacteriology, Dental caries research, Bacterial cultures

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Structure-activity study of the lantibiotic mutacin II from Streptococcus mutans T8 by a gene replacement strategy

Article Abstract:

Experiments were conducted to create a host-vector expression system for genetic manipulation of the lantibiotic mutacin II structural gene from Streptococcus mutans. A host strain was developed that contains all the genetic information for modification, export and processing of the mutated peptides to create an engineered mutacin. The cysteines were replaced with alanines to examine the role of the thioether bridges in the gene's antimicrobial activity.

Gene mutations, Gene mutation

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The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 are clustered and can be transferred en bloc

Article Abstract:

The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 have been studied by DNA sequencing analysis. Mutacin II is a ribosomally synthesized lantibiotic secreted by group II S. mutans. Its gene cluster is made up of seven specific open reading frames consisting of a regulator gene (mutR), the prepromutacin structural gene (mutA), a modifying protein (mutM), an ABC transporter (mutT) and an immunity cluster (mutFEG).

Bacterial genetics

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