The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation

Article Abstract:

Heterochromatic position effect variegation (PEV) results when genes translocated to positions adjacent to the heterochromatin become inactivated. A locus termed Su(var)2-5 exhibits a dosagedependent modification on PEV levels contains a region coding for the heterochromatin-associated protein HP-1. Characterization of Su(var)2-5 showed that HP-1 is an essential protein, functioning as part of an epigenetic mechanism capable of generating and maintaining an inactive chromatin stucture.The implications of HP-1 function on the mechanisms of developmental gene repression are discussed.

Genetic regulation, DNA binding proteins

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P transposon-induced dominant enhancer mutations of position-effect variegation in Drosophila melanogaster

Article Abstract:

Hybrid dysgenic crosses and mutator element transposition were used to isolate position-effect variegation modifier mutations induced by P transposons. Analysis of these modifier genes was undertaken together with spontaneous- and X-ray-induced enhancer mutations. Mapping and complementation results reveal that the frequency of the enhancer genes is equal to that of suppressor genes. Most of the enhancer genes was also shown to demonstrate paternal effects. Results of initial studies on the regulation of genetic expression during development is presented.

Variation (Biology), Animal mutation

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Observations on the induction of position effect variegation of euchromatic genes in Drosophila melanogaster

Article Abstract:

The heterochromatic regions which influence gene inactivation were examined using studies of position effect revertants for genes in the region associated with T(1;2)dor(super var7). Results revealed that a significant decrease or a complete disappearance of the position-effect occurred in spite of the retention of the 20-kb heterochromatic segment located beside the 1A-2B7-8 region. This indicates that juxtaposing a euchromatic region to heterochromatin is not enough to inactivate euchromatic genes.

Nucleotide sequence, Base sequence, Variegation, Variegation (Botany), X chromosome

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