The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection

Article Abstract:

High-affinity interactions between the CD4 receptor of target cells and the viral envelope glycoprotein gp120 leads to the onset of target cell HIV-1 infection. The central activity of CD4 as a coreceptor for T-cell stimulation is disrupted by the cell surface and intracellular interactions that continue throughout the duration and infection. Cell surface gp120 induces immune cytolysis susceptibility in CD4 molecules. Cell surface CD4 receptor downregulation results in a state of superinfection immunity, leading to intracellular interactions between HIV-1 and CD4 in infected cells.

Viruses, Virus receptors

---

Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa-B/Rel transcription factors

Article Abstract:

Dysfunction in HIV-infected myeloid cells may result in increased replication of the virus. Infected cells may undergo physiological changes that include the expression of receptors that can result in cytokine-induced activation and differentiation. Increased HIV-1 replication may then be mediated by increased activity of Nf-kappaB transcription factors. Secondary infections or antigenic challenges may lead to abnormal secretion of cytokines by these cells, contributing further to AIDS pathogenesis.

Genetic aspects, Genetic regulation, Cytokines, Virus replication

---

Pathogenesis of human immunodeficiency virus infection

Article Abstract:

The human immunodeficiency virus is transmitted vertically and horizontally mainly through body fluids. The viral infection basically involves the interaction with the CD-4 and other identified cell receptors. When viral entry has been completed, various intracellular mechanisms come into play which leads to either productive or latent infection. Host immune response had been observed to suppress the virus for a time. The activity of CD8 and a low virulence virus may be involved in this phenomena.

AIDS (Disease), Pathology, Virus-induced immunosuppression

Similar abstracts:

• Abstracts: Survival of human immunodeficiency virus (HIV), HIV-infected lymphocytes, and poliovirus in water. Protozoan bacterivory and Escherichia coli survival in drinking water distribution systems
• Abstracts: Seasonal variations of virus abundance and viral control of the bacterial production in a backwater system of the Danube River
• Abstracts: Reproductive characteristics of migratory golden eagles in Denali National Park, Alaska. Genetic variation and nesting Bald Eagles

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.