The importance of the five phosphoribosyl-pyrophosphate synthetase (Prs) gene products of Saccharomyces cerevisiae in the maintenance of cell integrity and the subcellular localization of Prs1p

Article Abstract:

Research has been conducted on phosphoribosyl-pyrophosphate synthetase (Prs) which catalyzes phosphoribosyl pyrophosphate synthesis. The authors report that Saccharomyces cerevisiae harbors unlinked structural genes encoding Prs polypeptides Prs1p-Prs5p, and that by using antisera against Prs1p epitopes they have determined Prs1p subcellular distribution via cellular fractionation and immunofluorescence analysis.

United Kingdom, Austria, All Other Basic Inorganic Chemical Manufacturing, Phosphorus & Compounds, Usage, Biosynthesis, Immunofluorescence, Fluorescent antibody technique, Antigenic determinants, Phosphorus compounds, Pyrophosphates

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Synergistic inhibition of APC/C by glycose and activated Ras proteins can be mediated by each of the Tpk1-3 proteins in Saccharomyces cerevisiae

Article Abstract:

Research has been conducted on anaphase-promoting complex/cyclosome which is a conserved ubiquitin ligase regulated by cell cycle checkpoint components and protein kinase. Results demonstrate that both glucose and activated Ras protein inhibit anaphase-promoting complex/cyclosome synergistically via cAMP/cAMP-dependent protein kinase in yeast.

Germany, Cell cycle, Bacterial proteins, Glucose, Chemical inhibitors, Dextrose

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Recombinant Saccharomyces cerevisiae expressing P450 in artificial digestive systems: a model for biodetoxication in the human digestive environment

Article Abstract:

Research has been conducted on model recombinant Saccharomyces cerevisiae which expresses heterologous CA4H. The survival rate and bioconversion activity of this recombinant have been investigated via the use of recombinant yeasts as convenient hosts for biodrug development, and the details are reported.

Netherlands, Research and Development in the Physical, Engineering, and Life Sciences, France, Genetic Engineering, Environmental aspects, Microbial ecology

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