The retinoblastoma protein and cell cycle control

Article Abstract:

The retinoblastoma tumor suppressor gene produces the pRB protein which controls the interaction of the cell cycle clock with transcription in the cells. Phosphorylation of pRB makes it inactive and the cell cycle continues after the G1 phase of the cell cycle. In many cancerous cells the pRB becomes inactive because of mutations and can no longer control the cell divisions. However for many cells to differentiate it is necessary for pRB to become inactive and the tissues containing cells which do not possess an active pRB undergo apoptosis and the defective cells are lost.

Research, Physiological aspects, Cell cycle, Cell proliferation, Retinoblastoma

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Rescue of cyclin D1 deficiency by knockin cyclin E

Article Abstract:

A study was conducted to analyze a mouse strain in which the coding sequences of the cyclin D1 gene have been deleted and replaced by those of human cyclin E. The replacement of cyclin D1 with cyclin E rescues all phenotypic manifestations of cyclin D1 deficiency and restores normal development in cyclin D1-dependent tissues. Results indicated that cyclin E can functionally replace cyclin D1 and that it is the major downstream target of cyclin D1.

Analysis, Genetic aspects, Cells (Biology), Mice, Mice (Rodents), Cells

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