The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo

Article Abstract:

The retinoic acid-inactivating enzyme CYP26 has been found to be necessary for setting up uneven distribution of retinoic acid along the anterio-posterior axis in mouse embryos. Mutant mice lacking CYP26 were generated to study the role of the enzyme. Retinoic acid is a derivative of vitamin A and plays a vital role in vertebrate development.

United States, Enzymes, Vertebrates, Vitamin A

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The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures

Article Abstract:

The retinoic acid (RA)-metabolizing enzyme, CYP26A1, has been studied by disrupting the murine Cyp26A1 gene and found to be required for normal development. Exposure to RA during formation of the antero-posterior body axis results in homeotic transformations along the vertebral column. CYP26A1 likely is needed to maintain given embryonic areas in an RA-depleted state to protect them against harmful effects of ectopic RA signaling.

France, Cytochrome P-450, Teratogenic agents

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FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse

Article Abstract:

FoxH1 (Fast), a Smad DNA-binding partner, has been found to specify the mouse anterior primitive streak, the anterior end of which gives rise to the node. An analysis of the role of FoxH1 has been carried out. Homozygous FoxH1 null embryos were found to lack a node, notochord and prechordal plate mesoderm. Fused somites and a flattened neural plate resulted. With other findings, the regulatory pathway was seen and shown to be essential for specification of the APS and regulation of axial patterning and mouse endoderm development.

Growth factors, DNA binding proteins, Gastrulation

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