The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

Article Abstract:

Small heterodimer partner (SHP), an atypical nuclear receptor inhibits the expression of steroidogenic genes and acts as gonadal gatekeeper of sexual maturation in male mice by playing a significant role in their testis. The analysis states that SHP keeps a check on the timing of male sexual maturation, as it plays a very important role in the metabolism of testicular androgen and retionic acid by slowing down the transcriptional activity of the retionic acid receptors.

Germ cells, Tretinoin, Clinical report

---

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1x

Article Abstract:

Hypoxia-inducible factor 1 (HIF-1) is a major regulator of developmental and cellular O2 homeostasis. The factor is induced as a response to physiologically relevant levels of hypoxia, which is an important physiological and developmental stimulus. mRNAs encoding glucose transporters and glycolytic enzymes were found reduced in embryonic cells with HIF-1x deficiency.

Analysis, Hypoxia, Anoxia, Cardiovascular research, Glycolysis

---

Insulin secretion: SIRT4 gets in on the act

Article Abstract:

SIRT4 is a mitochondrial sirtuin regulating glutamate dehydrogenase (GDH) activity through ADP-ribosylation. Findings suggest that SIRT4 controls insulin secretion in pancreatic [beta] cells in response to amino acids, fitting the notion that sirtuins control the mitochondrial energy supply.

Amino acids, Pancreatic beta cells, Glutamate dehydrogenase

Similar abstracts:

• Abstracts: The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. The binding of AP-1 clathrin adaptor particles to golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein
• Abstracts: Epiphytic cyanobacteria on Chara vulgaris are the main contributors to N2 fixation in rice fields. Insecticidal Bacillus thuringiensis silences Erwinia carotovora virulence by a new form of microbial antagonism, signal interference
• Abstracts: California blonde, a new recessive mutation in the deer mouse
• Abstracts: Microtubules are a general component of mRNA localization systems in Drosophila oocytes. NAADP and InsP3 play distinct roles at fertilization in starfish oocytes
• Abstracts: Ectoderm-mesenchyme and mesenchyme-mesenchyme interactions regulate Msx-1 expression and cellular differentiation in the murine limb bud

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.