The unfolding tale of the unfolded protein response

Article Abstract:

This review unfolds the story of the unfolded protein response (UPR) process encountered with surface and secreted proteins in yeast and mammalian systems. The UPR begins when protein maturation, which involves protein folding, is interrupted at the endoplasm reticulum. Data indicate that three gene products can initiate the UPR in yeast and mammals.

Research, Secretion, Physiological regulation, Protein synthesis, Yeast, Yeast (Food product), Protein biosynthesis

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

Article Abstract:

In the mammalian unfolded protein response process, two signaling systems meet at XBP1 molecule, whose mRNA is induced by ATF6 and spliced by IRE1 during endoplasm reticulum stress. This leads to the generation of transcription factor involved in the activation of mammalian unfolded protein response.

Genetic aspects, Endoplasmic reticulum, Enzyme activation

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Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

Article Abstract:

Results demonstrate that in C. elegans, ire-1 controls the splicing of endoplasm reticulum stress induced mRNA, which encodes the transcription factor XBP-1. Data indicate that splicing of xbp-1 mRNA is essential for activating the unfolded protein response.

Statistical Data Included, Cellular signal transduction

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