The value of molecular haplotypes in a family-based linkage study

Article Abstract:

A simulated study is used to compare the value of molecular haplotypes with the power of using standard genotyping in the context of a family-based linkage study. The results indicate that most of the increase in power is achieved by molecularly haplotyping a single individual in each family, thereby making it a valuable strategy for increasing the power of gene mapping studies of complex diseases.

Heterogeneous catalysis, Pedigree analysis, Clinical report

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Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows

Article Abstract:

A new approach for haplotype association analysis is proposed to tackle the problem of multiple degrees of freedom in the haplotype test. A large number of haplotypes could be handled by the method in association analyses more efficiently and effectively than do currently available approaches.

Single nucleotide polymorphisms

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A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to Schizophrenia

Article Abstract:

Random markers on chromosome 11q22-24 were initially selected for fine mapping and confirmation was performed by the study of an Aberdeen sample. The strongest allelic and haplotypic associations were found with markers within FXYD6 gene.

United States, Genetic aspects, Genetic markers, Schizophrenia, Genetic code

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