The vertebrate limb: a model system to study the HOX/HOM gene network during development and evolution

Article Abstract:

The HOX/HOM gene network encodes positional information for the development of the vertebrate limb. Temporal activation of a series of genes along the chromosome produces proteins that instruct cells where they are expressed. Organisms that develop in an anterior-posterior morphogenetic progression may express genes with the same mechanism. The effects of the HOX/HOM genes may be phylogenetically related to the segmentation process in insects and annelids.

Research, Developmental genetics, Extremities (Anatomy)

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Origin and evolution of the vertebrate vomeronasal system viewed through system-specific genes

Article Abstract:

The evolutionary studies of mammalian vomeronasal system (VNS)-specific genes, the evidence showing the presence and tissue-specific expression of the VNS-specific genes in teleosts, as well as co-expression patterns of these genes in specific regions of the teleost olfactory epithelium are described. The analysis has shown that a VNS precursor exists in teleosts and that its evolutionary origin predated the separation between teleosts and tetrapods.

Natural history, Nutritional aspects, Mammals

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Breaking colinearity in the mouse HoxD complex

Article Abstract:

A study was conducted to discover the molecular mechanism involved in the activation of vertebrate Hox genes. Results of experiments with mice suggest that activation of vertebrate Hox genes is done in a spatiotemporal sequence that explains their clustered organization. It was also found that a regulatory element found upstream of the cell complex is essential for preparing the early pattern of Hox gene colinear activation.

Analysis, Mice, Mice (Rodents), Genetic research

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