Three-site synapsis during Mu DNA transposition: a critical intermediate preceding engagement of the active site

Article Abstract:

Research indicates that the transposition process of the Mu bacteriophage DNA (Deoxyribonucleic acid) involves a DNA protein structure. A transpositional enhancer is responsible for mediating the catalysis of transposomes at the Mu ends. A three-site synaptic complex is also found at ends of the Mu phage together with the transcriptional enhancer called the LER (Left end-Enhancer-Right end) complex. The transposition reaction is inhibited by the substitution of a single base pair.

Physiological aspects, Translocation (Genetics)

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Molecular organization in site-specific recombination: the catalytic domain of bacteriophage HP1 integrase at 2.7 angstrom resolution

Article Abstract:

A study was conducted of the molecular organization in site-specific recombination. The isolated C-terminal domain of bacteriophage HP1 integrase interacts with the recombination site and contains the four catalytic residues conserved in the integrase family. Mutual interactions of the tail of one monomer with an adjacent monomer result in the formation of dimers which, consequently, lead to the antiparallel orientation of active-site clefts.

Genetic recombination, Binding sites (Biochemistry), Active sites (Biochemistry), Molecular genetics

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A hybrid vector for ligand-directed tumor targeting and molecular imaging

Article Abstract:

A system containing cis-elements from adeno-associated virus (AAV) and single-stranded bacteriophage is introduced. It is shown that AAV/phage (AAVP) provides superior tumor transduction over phage and that incorporation of inverted terminal repeats is associated with improved fate of the delivered transgene.

Science & research, Genetic research

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