Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo

Article Abstract:

The mechanism by which ELF-1, a glycosylphosphatidylinositol-anchored ligand, influences axon behavior was determined by testing its effects on retinal axon mapping in vivo and retinal axon guidance in vitro. Assays of ELF-1 during in vivo topographic mapping and in vitro retinotectal mapping revealed that ELF-1 may be used as an efficient retinotectal mapping label in establishing the spatial order of the neurons in the nervous system.

Usage, Nervous system, Axons, Ligands, Ligands (Chemistry), Cellular recognition

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Magnitude of binocular vision controlled by Islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding

Article Abstract:

Islet-2 (Isl2) specifies retinal ganglion cell (RGC) laterality by repressing an ipsilateral pathfinding program unique to ventral-temporal crescent (VTC) RGCs and involving the zinc finger transcription factor (Zic2) and the ephrin-B2 receptor (EphB1). This genetic hierarchy controls binocular vision by regulating the magnitude and source of ipsilateral projections and reveals unique retinal domains.

Science & research, Genetic transcription, Transcription (Genetics), Genetic research, Zinc finger proteins, Ganglion

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Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map

Article Abstract:

ELF-1 and Mek4 play key parts in retinotectal development and have properties predicted for topographic mapping labels. Cloning of ELF-1 shows matching expression gradients for the ELF-1 in the tectum and and its receptor Mek4 in the retina. Topographic maps with a specific spatial ordering of neuronal connections are a main feature of brain organization.

Abnormalities, Ligand binding (Biochemistry), Topographic maps

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