Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres

Article Abstract:

Histone acetylation is thought to mark and maintain transcriptionally active or inactive chromosomal domains via the cell cycle. Histone acetylation in centromere regulation has been observed. Fission yeast cells exposed to TSA a histone deacetylase inhibitor, interferes with marker gene repression and leads to chromosome loss, disrupting Swi6p localization. Fully functional centromere assembly is imprinted in the underacetylated state of centromeric chromatin.

Observations, Histones, Cell research, Cytological research

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CHD4/Mi-2beta activity is required for the positioning of the mesoderm/neuroectoderm boundary in Xenopus

Article Abstract:

The research on the embryonic development of Xenopus has led to the discovery of several signal proteins and extra cellular growth inhibitors. The developmental activities of CHD4/Mi-2beta in the control of the neuroectoderm/mesoderm boundaries by suppressing the transcription of Sip1, a neural-promoting gene, are reported.

Genetic aspects, Xenopus, Animal embryology, Genetic research

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RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing

Article Abstract:

The study shows that another Pol II subunit, Rbp7 has a specific role in pre-small interfering RNA (siRNA) transcription. In contrast to other Pol II subunits, Rpb7 promotes pre-siRNA transcription required for RNAinterference-directed chromatin silencing.

Centromeres, RNA interference

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