Traversing the conceptual divide between biological and statistical epistasis: Systems biology and a more modern synthesis

Article Abstract:

A study reviewed definitions and examples of biological and statistical epistasis and explored the relation between the two. The result gives necessary information regarding when the statistical evidence of epistasis in human populations imply underlying bimolecular interactions in the etiology of disease and also regarding when the biological interactions produce patterns of statistical epistasis.

Phenotype, Phenotypes, Genetic epistasis, Epistasis

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The importance of stress and genetic variation in human aggression

Article Abstract:

Reaction to stress seems to be a significant factor in precipitating aggressive episodes and individuals may vary in their ability to cope with stressful environments depending on their genetic composition. Common alleles of some serotonin pathway genes, including those involved in its degradation or its reuptake into pre-synaptic neurons, are shown to confer functional variation.

United States, Stress (Psychology), Aggressiveness (Psychology)

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The use of animal models in the study of the complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?

Article Abstract:

The controlling genetic background in animal studies can produce more consistent results and hence it is suggested that the failure to replicate human findings in the same diseases is due to the variation in interacting genes. Such contrasting nature of findings from different study designs shows the importance of non-additive genetic effects on human disease.

Diseases

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