WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo

Article Abstract:

Three WNT factors have been shown to signal through beta-catenin function as critical regulators of the FGF-8/FGF-10 loop. Induction of Fgf-8 in the limb ectoderm by FGF-10 is mediated by the induction of Wnt-a. Three WNT signals mediated by beta-catenin control both limb initiation and apical ectodermal ridge (AER) induction in the vertebrate embryo.

Extremities (Anatomy), Ectoderm, Chick embryo

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The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification

Article Abstract:

The novel tyrosine kinase ZAK1, cAMP-activated and a nonreceptor, activates GSK3 to direct the specification of cell fate in Dictyostelium. Likely similar mechanisms antagonize Wnt/wingless (wg) signaling for metazoan cell fate specification. ZAK1 is downstream of 7-TM cAMP receptor signaling.

Cell differentiation, Dictyostelium

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Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos

Article Abstract:

Research has been conducted on left-right asymmetry establishment during vertebrate embryogenesis. The authors report the existence of the mechanism which involves Notch activity translating initial symmetry breaking event into asymmetric gene expression.

Spain, Analysis, Physiological aspects, Vertebrates, Developmental biology, Gene expression, Genetic research, Animal embryo

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