What have tissue culture studies told us about the development of oligodendrocytes?

Article Abstract:

The bipotential O-2A cell derived from optic nerve tissue cultures may either generate oligodendrocytes or type-2 astrocyte under different conditions. Experiments using antibodies against ganglioside GD3 have pointed to GD3+ cells as oligodendrocyte precursors and in vivo counterparts of the O-2A cells. However, there is still insufficient knowledge about astrocyte phenotypes in vivo and their developmental profile to clearly establish type-2 astrocyte's existence in vivo. Finally, studies indicate that O-2A cells are equivalent to oligodendroblasts described in vivo.

Usage, Growth, Neurons, Tissue culture, Oligodendroglia

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mRNPs take shape by CLIPPING and PAIRING

Article Abstract:

The relative strengths and limitations of the three new methods that are designed to identify the RNA-binding proteins (RBP)-RNA interactions are discussed. The development of CLIP, PAIR and trimolecular fluorescence has helped in understanding the RBP-RNA interactions that occur in cells and will thus help define the human interactome.

Science & research, New York, Analysis, Genetic aspects, Gel electrophoresis, Cell metabolism, Ribonucleoproteins

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