When contractile proteins go bad: The sarcomere and skeletal muscle disease

Article Abstract:

The skeletal muscle diseases caused by mutation of sarcomeric proteins are reviewed with a focus on the diseases caused by the two fundamental sarcomeric proteins, actins and myosin and some possible approaches to treatment are discussed. Mutations in a large number of the protein components of the sarcomere are demonstrated to cause various skeletal and cardiac muscle diseases.

United States, Gene mutations, Gene mutation, Genetic aspects, Muscles, Bacteria, Pathogenic, Pathogenic bacteria, Skeletal muscle

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Chaperoning prions: The cellular machinery for propagating an infectious protein?

Article Abstract:

The role of molecular chaperones in yeast prion propagation is reviewed and a model that could explain the role of various classes of molecular chaperones and their co-chaperones is described. Prions could exploit the molecular chaperone machinery in the cell to ensure stable propagation of the infectious, aggregation prone form.

Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Prions, Prions (Proteins), Brewer's yeast, Saccharomyces cerevisiae, Molecular chaperones

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