mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3prime end

Article Abstract:

Two proteins that bind to the differentiation control element (DICE) were purified from rabbit reticulocytes and analyzed to characterize their role in erythroid differentiation and messenger RNA (mRNA) silencing. The two DICE-binding proteins designated as, hnRNP K and hnRNP E1 silenced internal ribosomal entry site- and cap-dependent translation by preventing the assembly of 80S ribosomes. Furthermore, hnRNP K and hnRNP E1 acted as specific cytoplasmic regulatory protein components of 15-lipoxygenase messenger RNA translation.

Research, Cell differentiation, Erythrocytes, Red blood cells, Genetic translation, Translation (Genetics)

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The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site

Article Abstract:

Research has been conducted on toxin-antitoxin pair RelE-RelB encoded by Escherichia coli relB operon. Results demonstrate that RelE cleaves mRNA in the ribosomal A site with high codon specificity.

Denmark, Sweden, Analysis, Physiological aspects, Escherichia coli, Bacterial toxins, Gene expression, Ribosomes, Cell research, Cytological research, Codon, Codons

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