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G-protein-coupled receptors as targets for gene transfer vectors using natural small-molecule ligands

Article Abstract:

Researchers from the University of North Carolina used G-protein-coupled receptors as target for vectors in the treatment of cystic fibrosis using small-molecule agonists.

Author: Kreda, Silvia M., Pickles, Raymond J., Lazarowski, Eduardo R., Boucher, Richard C.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000

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A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies

Article Abstract:

A framework for comparisons of gene expression data across platforms and laboratories is described. It is demonstrated that after stringent preprocessing, commercial arrays were more consistent than in-house arrays, and by most measures, one dye platforms were more consistent than two-dye platforms.

Author: Church, George M., Freeman, Mason W., Punzo, Claudio, Kuo, Winston Patrick, Whipple, Mark E., Jenssen, Tor-Kristian, Ohno-Machado, Lucila, Seed, Brian, Fang Liu, Trimarchi, Jeff, Lombardi, Michael, Sarang, Jasjit, Maysuria, Malini, Serikawa, Kyle, Sun Young Lee, McCrann, Donald, Kang, Jason, Shearstone, Jeffrey R., Burke, Jocelyn, Park, Daniel J., Wang, Xiaowei, Rector, Trent L., Ricciardi-Castagnoli Paola, Perrin, Steven, Choi, Sangdun, Bumgarner, Roger, Ju Han Kim, Short, Glenn F., Jensen, Roderick, Hoving, Eivind, Cepko, Connie L., Park, Peter
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
Forecasts, trends, outlooks, Epilepsy & Muscle Disease R&D, Administration of Public Health Programs, Health Research Programs, Research, Forecasts and trends, Market trend/market analysis, Gene expression, DNA microarrays, Medicine, Experimental

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Analysis of transcription complexes and effects of ligands by microelectrospray ionization mass spectrometry

Article Abstract:

Researchers studied the human vitamin D receptor and retinoid X receptor using rapid buffer exchange gel filtration and microelectrospray ionization mass spectrometry. Charts, graphs, and a photograph are included.

Author: et al., Craig, Theodore A.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1999
Vitamin, Nutrient & Hematinic Preps, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Brief Article

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Subjects list: United States, Medical research
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