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A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells

Article Abstract:

The effect of chemically synthesized small interfering RNAs (siRNAs) on mammalian double-stranded RNS (dsRNA)-activated signaling pathways is analyzed to find out the basis of the nonspecific activities. The results help in enabling the rational design of siRNAs that avoid nonspecific effects or, alternatively, that induce bystander effects to potentially enhance the efficacy of siRNA-based treatments of viral infections or cancer.

Author: Williams, Bryan R.G., Fujita, Takashi, Behlke, Mark A., Marques, Joao Trindade, Devosse, Thalie, Die Wang, Zamanian-Daryoush, Maryam, Serbinowski, Paul, Hartmann, Rune
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
Science & research, Research, Physiological aspects, Genetic aspects, Virus diseases, Cancer, Mammals, RNA interference

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Taming ricin toxin

Article Abstract:

Ricin is a potent toxin and its cytocidal properties are exploited in cancer treatment. A single point mutation in ricin toxin can eliminate vascular leak syndrome without compromising the toxin's enzymatic action.

Author: Kreitman, Robert J.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2003
Methods, Usage, Blood circulation disorders, Vascular diseases, Ricin

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Subjects list: Care and treatment, United States, Cancer treatment
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