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Connecting genes, drugs and diseases

Article Abstract:

Several chemical genetic strategies have linked gene profile signatures to drug activity patterns and mechanisms of action, but none of them have proved useful till date. Researchers have currently outlined a large-scale chemical genetic approach with the potential for connecting genes and drug action with human diseases that offers promise for both basic and applied biomedical research.

Author: Weinstein, John N., Pommier, Yves
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
Phenotype, Phenotypes, Biochemical genetics

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Genetic sequences: how are they patented?

Article Abstract:

Genetic sequence includes a description of the gene's composition and the function or utility assigned to it that helps in finding the number of patents. A survey shows that the validity of genetic sequence arises due to the way in which genetic sequences are claimed in granted patents that are heterogeneous and imprecise.

Author: Dufresne, Guillaume, Duval, Manuel
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors, Patent Programs, Surveys, Patents, Patent/copyright issue

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A SLAMS dunk for cancer regulators

Article Abstract:

The gene regulators of cancer are identified by integrating the data on gene expression data with gene copy number data by using a novel approach called stepwise linkage analysis of microarray signatures (SLAMS). The advantages and limitations of SLAMS method are discussed.

Author: Chinnaiyan, Arul M., Kumar-Sinha, Chandan
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
Genetic aspects, Cancer, Genetic regulation

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Subjects list: Research, United States, Gene expression
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