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Eco-friendly insect management

Article Abstract:

A genetic method called the Sterile Insect Technique (SIT) can be used to successfully suppress economically important pest species and involves mass production of the target pest, sterilization by irradiation release over entire regions of large numbers of sterilized insects. Genetic engineering promises to improve a technique for controlling medflies that avoids chemical insecticides.

Author: Wimmer, Ernst A.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
Environmental aspects, Technology application, Insect sterilization

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Reverse engineering gene regulatory networks

Article Abstract:

Reconstruction of biological network can be improved by using an information theoretic algorithm called ARACNe that prunes away potentially indirect interactions. Details of the reverse engineering that elucidates the structure of a system by reasoning backwards from observations of its behavior are discussed.

Author: Hartemink, Alexander J.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
DNA synthesis

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Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice

Article Abstract:

Vascular leak syndrome is considered as a major and dose-limiting side effect of immunotoxins and cytokines. A three-dimensional structure is evaluated as immunotoxins for activity, ability to induce pulmonary vascular leak in mice, pharmacokinetics and activity in tumor-xenografted mice.

Author: Smallshaw, Joan E., Ghetie, Victor, Rizo, Jose, Fulmer, John R., Trahan, Linda L., Ghetie, Maria-Ana, Vitetta, Ellen S.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2003
Product development, Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Immunotoxins, Care and treatment, Blood circulation disorders, Vascular diseases, Antibody-toxin conjugates

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Subjects list: Research, United States, Genetic engineering
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