Evolution of a T7 RNA polymerase variant that transcribes 2'-o-methyl RNA

Article Abstract:

The original procedure to identify polymerases that can efficiently incorporate multiple modified nucleotides at the 2'position of the ribose is described. The modified RNA and DNA molecules have novel properties that their natural counterparts do not possess, like better resistance to degradation in cells and improved pharmacokinetic behavior.

Biological Product (except Diagnostic) Manufacturing, Drugs, Deoxyribonucleic Acid, Nucleic Acid Derivatives, Research, DNA, RNA polymerases, Nucleotides

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Switching nucleic acids for antibodies. Can ribozymes replace antibodies i future array formats for proteomics and metabolomics?

Article Abstract:

Research into DNA arrays have show how large-scale antibody arrays could eventually be used to quantify levels of serum proteins.

Monoclonal Antibodies for Diagnosis, Monoclonal antibodies, Diagnosis

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Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome

Article Abstract:

Researchers in the U.S. and Japan devised an approach to phosphoprotein enrichment and mapping

Japan, Strategic alliances, Diagnostic Chemicals, Diagnostic reagents

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