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In silico pharmacogenetics of warfarin metabolism

Article Abstract:

The murine haplotype-based computational method is used to identify a genetic factor regulating the metabolism of warfarin, an anticoagulant with a narrow therapeutic index and a large variation in individual dosing. The analysis has shown that genetic variants responsible for interindividual pharmacokinetic differences in drug metabolism can be detected by computational genetic analysis in mice.

Author: Weller, Paul, Yingying Guo, Farrell, Erin, Peltz, Gary, Cheung, Paul, Fitch, Bill, Clark, Douglas, Masjedizadeh, Mohammad, Shao-yong Wu, Jianmei Wang, Guochun Liao, Zhaomei Zhang, Allard, John, Cheng, Janet, Anh Nguyen, Sharon, Jiang, Shafer, Steve, Usuka, Jonathan
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
Health aspects, Dosage and administration, Warfarin

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Putting pharmacogenetics into practice

Article Abstract:

The results of the study assessing the progress in exploring pharmacogenetics challenges for those attempting to apply this knowledge are presented. It is suggested that the successful integration of pharmacogenetics into healthcare systems may rely on many independent factor like the attractiveness of pharmacogenetics as an investment area.

Author: Nightingale, Paul, Ryan, Jim, Ibarreta, Dolores, Hopkins, Micheal M., Gaisser, Sibylle, Enzing, Christien M., Martin, Paul A., Lewis, Graham, Detmar, Symone, van den Akker-van Marle, M. Elske, Hedgecoe, Adam M., Dreiling, Marieke, Hartig, K. Juliane, Vullings, Wieneke, Forde, Tony
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
HEALTH SERVICES, Health care industry

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Towards quality assurance and harmonization of genetic testing services in the European Union

Article Abstract:

The current scope and quality of genetic testing services in Europe are described. Several proposal options to ensure the highest quality services, harmonized quality control and better cross-border cooperation of European genetic testing services are also mentioned.

Author: Ibarreta, Dolores, Elles, Robert, Rodriguez-Cerezo, Emilio, Dequeker, Elisabeth
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
Europe, Services information, Analysis, Services, Genetic screening, Genetic testing

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Subjects list: Research, United States, Pharmacogenetics, Pharmacogenomics
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