Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complimentary vectors

Article Abstract:

Splitting the adeno-associated virus (rAAV) vectors into two can increase the transduction efficiency and quantitation of the recombinant protein allowing for the development of gene therapy strategies with large cDNAs.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Viral Disease R&D, Viral research

---

Robust expansion of human hepatocytes in [Fah.sup.-I-]/[Rag2.sup.-I-]/[II2rg.sup.-I-] mice

Article Abstract:

Severely immunodeficient, fumarylacetoacetate hydrolase (Fah)-deficient mice is generated in order to provide a useful hepatic xenorepopulation system. The expanded cells have exhibited typical human drug metabolism and this system has provided a robust platform for producing high-quality human hepatocytes for tissue culture, which is useful for testing the toxicity of drug metabolites.

Usage, Evaluation, Drugs, Identification and classification, Liver cells, Hepatocytes, Tissue culture, Drug toxicity

---

AAV vectors and tumorigenicity

Article Abstract:

Researchers have found that neonatal mice treated with recombinant adeno-associated viral (rAAV) vectors have higher incidence of hepatocellular carcinoma. Several incidences show that rAAV vectors contribute towards malignancy.

Animal specialties, not elsewhere classified, Laboratory Animals, All Other Animal Production, Health aspects, Risk factors, Adenoviruses, Virus-vector relationships, Hepatoma, Hepatocellular carcinoma

Similar abstracts:

• Abstracts: The effect of Louisiana's community property laws on financial planning with life insurance. 21st century life insurance needs of the affluent
• Abstracts: Comparison between using spectral analysis of electrogonimeter data and observational analysis to quantify repetitive motion and ergonomic changes in cyclical industrial work
• Abstracts: Learning from competing partners: outcomes and durations of scale and link alliances in Europe, North America and Asia
• Abstracts: Employee benefits and the Society of Financial Service Professionals. Forming an employee benefit study group
• Abstracts: 'Nonqualified deferred com plans' help firms retain key employees. Stock plans reward employees, protect ownership level

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.