The single cell as a microplate well

Article Abstract:

Directed evolution is currently the most rapid route to engineer desired protein properties.With the broad availability of inventive screening and mutagenesis strategies new applications of enzymes and antibodies have blosssomed.

Pharmaceutical Preparation Manufacturing, Enzymes, Other Basic Organic Chemical Manufacturing, Biological products exc. diagnostic, Protein, Antibodies for Human Use, Brief Article, Proteins, Human nutrition

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Integrating cell-level kinetic modeling into the design of engineered protein therapeutics

Article Abstract:

The greater integration of kinetic mathematical modeling into the preclinical development of drug targets into protein biopharmaceuticals is discussed. The application of this paradigm to the evidence based generation of the target product profile used in drug development would reduce risk through improved quantitative understanding of the mechanisms of drug action.

Methods, Protein research, Pharmaceutical research, Biopharmaceutics, Biopharmaceuticals

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Computational design of antibody-affinity improvement beyond in vivo maturation

Article Abstract:

An iterative computational design procedure for antibody-affinity maturation in vivo is described. Results show computational capabilities for increasing the development of protein reagents and therapeutics.

Usage, Protein binding, Computer simulation, Computer-generated environments, Viral antibodies, Computational biology

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