Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin

Article Abstract:

Anthrax toxin protective antigen (PrAg) mutants were created with mutations affecting different lethal factor (LF)-binding subsites and containing either urokinase plasminogen activator (uPA) or matrix metalloproteinase (MMP) cleavage sites. It is shown that anthrax toxin, and by implication other multimeric toxins, offer excellent opportunities to introduce multiple-specificity determinants and thereby achieving high therapeutic indices.

Science & research, Research, Tissue plasminogen activator, Lethal mutation, Urokinase

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Identification of anti-repressor elements that confer high and stable protein production in mammalian cells

Article Abstract:

A screening technology was developed to suppress chromatin-associated repression of transgenic proteins in mammalian cells.

Netherlands

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Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis

Article Abstract:

Different protein interactions in different types of cells are discussed.

Cover Story

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