Mapping of conserved RNA secondary structures predicts thousands of functional noncoding RNAs in the human genome
Article Abstract:
A study presents a comparative screen of vertebrate genomes for structural noncoding ribonucleic acids (ncRNAs), which evaluates conserved genomic deoxyribonucleic acid (DNA) sequences for signatures of structural conservation of base-pairing patterns and exceptional thermodynamic stability. A comparison with available tiling array data reveals that more than 40 percent of the predicted structured RNAs overlap with experimentally detected sites of transcription.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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Promoter prediction analysis on the whole human genome
Article Abstract:
The promoter prediction programs (PPPs) are important for in silico gene discovery without support from expressed tag (EST)/cDNA/mRNA sequences, in the analysis of gene regulation and in genome annotation. The comprehensive analysis of PPPs reveals that no program simultaneously achieves sensitivity and positive predictive value and some PPPs perform even worse than or close to, pure random guessing.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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Widespread occurrence of antisense transcription in the human genome
Article Abstract:
The extent of antisense transcription in the human genome is examined by analyzing the public databases of expresses sequences in order to identity sense-antisense transcriptional units on opposite DNA strands of the same genomic locus. The findings indicate that the occurrence of antisense transcription is a very common phenomenon in the human genome.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2003
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